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Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

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dc.contributor.authorWoo, Yong
dc.contributor.authorAnsari, Hifzur
dc.contributor.authorOtto, Thomas
dc.contributor.authorLinger, Christen
dc.contributor.authorOlisko, Martin
dc.contributor.authorMichálek, Jan
dc.contributor.authorSaxena, Alka
dc.contributor.authorShanmugam, Dhanasekaran
dc.contributor.authorTayyrov, Annageldi
dc.contributor.authorVeluchamy, Alaguraj
dc.contributor.authorAli, Shajahan
dc.contributor.authorBernal, Alex
dc.contributor.authorCampo, Javier del
dc.contributor.authorCihlár, Jaromir
dc.contributor.authorFlegontov, Pavel
dc.contributor.authorGornik, Sebastian
dc.contributor.authorHajduskova, Eva
dc.contributor.authorHorák, Ales
dc.contributor.authorJanouskovec, Jan
dc.contributor.authorKatris, Nicholas
dc.contributor.authorMast, Fred
dc.contributor.authorMiranda Saavedra, Diego
dc.contributor.authorMourier, Tobias
dc.contributor.authorNaeem, Raeece
dc.contributor.authorNair, Mridul
dc.contributor.authorPanigrahi, Aswini
dc.contributor.authorRawlings, Neil
dc.contributor.authorPadron Regalado, Eriko
dc.contributor.authorRamaprasad, Abhinay
dc.contributor.authorSamad, Nadira
dc.contributor.authorTomcala, Ales
dc.contributor.authorWilkes, Jon
dc.contributor.authorNeafsey, Daniel
dc.contributor.authorDoerig, Christian
dc.contributor.authorBowler, Chris
dc.contributor.authorKeeling, Patrick
dc.contributor.authorRoos, David
dc.contributor.authorDacks, Joel
dc.contributor.authorTempleton, Thomas
dc.contributor.authorWaller, Ross
dc.contributor.authorLukes, Julius
dc.contributor.authorOborník, Miroslav
dc.contributor.authorPain, Arnab
dc.contributor.rorhttps://ror.org/02jjdwm75
dc.date.accessioned2024-07-08T13:14:56Z
dc.date.accessioned2024-09-16T11:20:44Z
dc.date.available2024-07-08T13:14:56Z
dc.date.available2024-09-16T11:20:44Z
dc.date.issued2015
dc.description.abstractThe eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular parasites of humans and animals with immense socio-economic and health impacts. We sequenced nuclear genomes of Chromera velia and Vitrella brassicaformis,free-living non-parasitic photosynthetic algae closely related to apicomplexans. Proteins from key metabolic pathways and from the endomembrane trafficking systems associated with a free-living lifestyle have been progressively and non-randomly lost during adaptation to parasitism. The free-living ancestor contained a broad repertoire of genes many of which were repurposed for parasitic processes,such as extracellular proteins,components of a motility apparatus,and DNA- and RNA-binding protein families. Based on transcriptome analyses across 36 environmental conditions,Chromera orthologs of apicomplexan invasion-related motility genes were co-regulated with genes encoding the flagellar apparatus,supporting the functional contribution of flagella to the evolution of invasion machinery. This study provides insights into how obligate parasites with diverse life strategies arose from a once free-living phototrophic marine alga. © Woo et al.
dc.description.peerreviewedyes
dc.description.statusPublished
dc.formatapplication/pdf
dc.identifier.citationWoo, Y. H., Ansari, H., Otto, T. D., Klinger, C. M., Kolisko, M., Michálek, J., ... & Pain, A. (2015). Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites. elife, 4, e06974. https://doi.org/10.7554/eLife.06974
dc.identifier.doihttps://doi.org/10.7554/eLife.06974
dc.identifier.issn2050084X
dc.identifier.officialurlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84937408158&doi=10.7554%2feLife.06974&partnerID=40&md5=3a5be66b01175ac7eadf7eb0825bb36e
dc.identifier.urihttps://hdl.handle.net/20.500.14417/3282
dc.issue.numberJULY 2015
dc.journal.titleeLife
dc.language.isoen
dc.page.final41
dc.page.initial1
dc.page.total16
dc.publishereLife Sciences Publications Ltd
dc.relation.departmentFinance
dc.relation.entityIE University
dc.relation.schoolIE Business School
dc.rightsAttribution 4,0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.otherAlga
dc.subject.otherApicomplexa
dc.subject.otherChromera velia
dc.subject.otherGene expression
dc.subject.otherGenome analysis
dc.subject.otherHost parasite interaction
dc.subject.otherMolecular evolution
dc.subject.otherNonhuman
dc.subject.otherParasite
dc.subject.otherPhylogeny
dc.subject.otherPolymerase chain reaction
dc.subject.otherProtein localization
dc.subject.otherRNA isolation
dc.subject.otherSequence alignment
dc.subject.otherTranscription regulation
dc.subject.otherVitrella brassicaformis
dc.subject.otherAlveolata
dc.subject.otherChemistry
dc.subject.otherDNA sequence
dc.subject.otherGene expression profiling
dc.subject.otherGenetics
dc.subject.otherMolecular genetics
dc.subject.otherAlgae
dc.subject.otherAnimalia
dc.subject.otherEukaryota
dc.subject.otherAlgal DNA
dc.subject.otherAlveolata
dc.subject.otherDNA
dc.subject.otherAlgal
dc.subject.otherEvolution
dc.subject.otherMolecular
dc.subject.otherGene Expression Profiling
dc.subject.otherMolecular Sequence Data
dc.subject.otherSequence Analysis
dc.titleChromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
dc.typeinfo:eu-repo/semantics/article
dc.version.typeinfo:eu-repo/semantics/publishedVersion
dc.volume.number4
dspace.entity.typePublication
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