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Molecular insights into chronotype and time-of-day effects on decision-making

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dc.contributor.authorIngram, Krista
dc.contributor.authorAy, Ahmet
dc.contributor.authorKwon, Soo Bin
dc.contributor.authorWoods, Kerri
dc.contributor.authorEscobar, Sue
dc.contributor.authorGordon, Molly
dc.contributor.authorSmith, Isaac
dc.contributor.authorBearden, Neil
dc.contributor.authorFilipowicz, Allan
dc.contributor.authorJain, Kriti
dc.contributor.rorhttps://ror.org/02jjdwm75
dc.date.accessioned2024-07-08T13:14:55Z
dc.date.available2024-07-08T13:14:55Z
dc.date.issued2016
dc.description.abstractRecent reports highlight that human decision-making is influenced by the time of day and whether one is a morning or evening person (i.e.,chronotype). Here,we test whether these behavioral effects are associated with endogenous biological rhythms. We asked participants to complete two well-established decision-making tasks in the morning or evening: the matrix task (an ethical decision task) and the balloon analog risk task (BART; a risk-taking task),and we measured their chronotype in two ways. First,participants completed a self-report measure,the Horne-Östberg Morningness-Eveningness Questionnaire (MEQ). Second,we measured the expression of two circadian clock-regulated genes - Per3 and Nr1d2 - from peripheral clock cells in participants' hair follicle samples. Using a cosinor model,we estimated the phase of the peripheral clock and assigned RNA chronotypes to participants with advanced (larks) or delayed (owls) phases. The behavioral data were analyzed independently for self-reported (MEQ) and RNA-based chronotypes. We find that significant chronotype and/or time-of-day effects between larks and owls in decision-making tasks occur only in RNA-based chronotypes. Our results provide evidence that time-of-day effects on decision-making can be explained by phase differences in oscillating clock genes and suggest that variation in the molecular clockwork may influence inter-individual differences in decision-making behavior.
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dc.identifier.citationIngram, K. K., Ay, A., Kwon, S. B., Woods, K., Escobar, S., Gordon, M., ... & Jain, K. (2016). Molecular insights into chronotype and time-of-day effects on decision-making. Scientific Reports, 6(1), 29-92.
dc.identifier.doihttps://doi.org/10.1038/srep29392
dc.identifier.issn20452322
dc.identifier.officialurlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84978101079&doi=10.1038%2fsrep29392&partnerID=40&md5=96f89177d2a9a17193d052dd4aacaa74
dc.identifier.urihttps://hdl.handle.net/20.500.14417/3094
dc.journal.titleScientific Reports
dc.language.isoeng
dc.page.total12
dc.publisherNature Publishing Group
dc.relation.departmentHuman Resources & Organisational Behaviour
dc.relation.entityIE University
dc.relation.schoolIE Business School
dc.rightsAttribution 4,0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.othercell receptor
dc.subject.othercircadian rhythm signaling protein
dc.subject.otherNR1D2 protein
dc.subject.otherhuman
dc.subject.otherPER3 protein
dc.subject.otherhuman
dc.subject.otherrepressor protein
dc.subject.otherchemistry
dc.subject.othercircadian rhythm
dc.subject.otherdecision making
dc.subject.otherfemale
dc.subject.othergenetics
dc.subject.otherhair follicle
dc.subject.otherhuman
dc.subject.othermale
dc.subject.otherself report
dc.subject.othersleep
dc.subject.othertheoretical model
dc.subject.othertime factor
dc.subject.otheryoung adult
dc.subject.otherCircadian Rhythm
dc.subject.otherDecision Making
dc.subject.otherFemale
dc.subject.otherHair Follicle
dc.subject.otherHumans
dc.subject.otherMale
dc.subject.otherModels
dc.subject.otherTheoretical
dc.subject.otherPeriod Circadian Proteins
dc.subject.otherReceptors
dc.subject.otherCytoplasmic and Nuclear
dc.subject.otherRepressor Proteins
dc.subject.otherSelf Report
dc.subject.otherSleep
dc.subject.otherTime Factors
dc.subject.otherYoung Adult
dc.titleMolecular insights into chronotype and time-of-day effects on decision-making
dc.typeinfo:eu-repo/semantics/article
dc.version.typeinfo:eu-repo/semantics/publishedVersion
dc.volume.number6
dspace.entity.typePublication
person.identifier.scopus-author-id7005886727
person.identifier.scopus-author-id36807941500
person.identifier.scopus-author-id57190179882
person.identifier.scopus-author-id57190174014
person.identifier.scopus-author-id57190175227
person.identifier.scopus-author-id57190171810
person.identifier.scopus-author-id36615600400
person.identifier.scopus-author-id56323351500
person.identifier.scopus-author-id57191380656
person.identifier.scopus-author-id41861776800
relation.isAuthorOfPublication6f3f29e3-60b2-4801-9a85-612cddb42f4a
relation.isAuthorOfPublication.latestForDiscovery6f3f29e3-60b2-4801-9a85-612cddb42f4a
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